Hepatitis C virus alternate reading frame protein decreases interferon-α secretion in peripheral blood mononuclear cells
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus in peripheral blood mononuclear cells.
RNA extracted from plasma and peripheral blood mononuclear cells of patients with chronic hepatitis C were used as the template for reverse transcription followed by double in vitro enzymatic amplification with nested primers. Hepatitis C virus was detected in 14 of 15 (93.3%) plasma specimens and in 8 of 15 (53.3%) peripheral blood mononuclear cell specimens obtained from patients with chronic...
متن کاملComparison of Hepatitis C Genotypes in Plasma and Peripheral Blood Mononuclear Cells (PMBCs) in Hepatitis C-Infected Patients
Abstract Background and Aims: The Hepatitis C Virus (HCV) is essentially hepatotropic but virus compartment has also been found in other important extra hepatic sites. Detection of HCV RNA in extra hepatic reservoirs such as peripheral blood mononuclear cells (PBMCs) is important for determining of disease progression and effective treatment. The present study aimed to determine of differe...
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objective: the effect of interleukin (il)-29, a new therapeutic agent similar to type i interferons (ifns), on ifn-α secretion of human plasmacytoid dendritic cells (pdcs) has not been studied. therefore, in this study, we aimed to clarify the effect of il-29 on ifn-α secretion of pdcs using human peripheral blood mononuclear cells (pbmcs) in the presence of cytosine-phosphate-guanosinemotif-co...
متن کاملSeroconversion to hepatitis C virus alternate reading frame protein during acute infection.
UNLABELLED The existence of hepatitis C virus (HCV) proteins encoded by alternate reading frames overlapping the core-encoding region has been suggested. Several mechanisms of production have been postulated, and the functions of these proteins in the HCV life cycle remain unknown. We analyzed cases of seroconversion to an alternate reading frame protein in a group of 17 patients infected by on...
متن کاملEffect of Interleukin-29 on Interferon-α Secretion by Peripheral Blood Mononuclear Cells
OBJECTIVE The effect of interleukin (IL)-29, a new therapeutic agent similar to type I interferons (IFNs), on IFN-α secretion of human plasmacytoid dendritic cells (pDCs) has not been studied. Therefore, in this study, we aimed to clarify the effect of IL-29 on IFN-α secretion of pDCs using human peripheral blood mononuclear cells (PBMCs) in the presence of cytosine-phosphate-guanosinemotif-con...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2013
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2013.1816